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Quality Factory Supply 99% Pure METHYL 2-CHLORONICOTINATE 40134-18-7 with Efficient Delivery
- Molecular Formula: C7H6ClNO2
- Molecular Weight: 171.583
- Appearance/Colour: white or almost white solid
- Vapor Pressure: 0.0429mmHg at 25°C
- Melting Point: 122-124oC
- Refractive Index: n 20/D 1.537
- Boiling Point: 238.2 °C at 760 mmHg
- PKA: -1.39±0.10(Predicted)
- Flash Point: 97.9 °C
- PSA： 39.19000
- Density: 1.294 g/cm3
- LogP: 1.52160
METHYL 2-CHLORONICOTINATE(Cas 40134-18-7) Usage
|
General Description |
Methyl 2-chloronicotinate is a chemical compound that belongs to the class of nicotinate derivatives. It is a derivative of nicotinic acid, also known as vitamin B3. METHYL 2-CHLORONICOTINATE is widely used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. Methyl 2-chloronicotinate is known for its mild, pleasant odor and it is commonly used as a flavoring agent in the food industry. It is also utilized as an intermediate in the production of agrochemicals, dyes, and other organic compounds. This chemical is considered to have low toxicity and is generally safe for use with proper handling and precautions. |
InChI:InChI=1/C7H6ClNO2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3
40134-18-7 Relevant articles
Preparation method of 2-chloro-N, N-dimethyl nicotinamide
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Paragraph 0010; 0025-0026; 0028-0029; 0031-0032, (2021/03/13)
The invention belongs to the technical f...
LIBRARIES OF PYRIDINE-CONTAINING MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
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Paragraph 00221, (2019/01/11)
The present disclosure relates to novel ...
A ultrasonic process for synthesizing 2 - halogenated nicotinate and intermediates thereof
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Paragraph 0057; 0058; 0061, (2018/04/21)
The invention discloses a method for syn...
A microwave synthesis 2 - halogenated nicotinate and intermediates thereof
-
Paragraph 0034; 0035, (2018/05/16)
The invention discloses a method for syn...
40134-18-7 Process route
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-
67-56-1
methanol
-
-
2942-59-8
2-chloronicotinic acid
-
-
40134-18-7
methyl 2-chloropyridine-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
for 8h;
Reflux;
|
93%
|
|
2-chloronicotinic acid;
With
oxalyl dichloride;
N,N-dimethyl-formamide;
In
dichloromethane;
at 20 ℃;
for 3h;
methanol;
With
triethylamine;
In
dichloromethane;
for 0.5h;
Cooling with ice;
With
sodium hydrogencarbonate;
In
water;
|
86%
|
|
With
trimethyl orthoformate;
at 150 ℃;
for 0.333333h;
Microwave irradiation;
|
67%
|
|
With
thionyl chloride;
|
|
|
methanol; 2-chloronicotinic acid;
With
sulfuric acid;
for 4h;
Heating / reflux;
With
sodium hydrogencarbonate;
In
water;
|
|
|
2-chloronicotinic acid;
With
thionyl chloride;
In
dichloromethane;
at 40 ℃;
methanol;
In
dichloromethane;
at 20 ℃;
|
|
|
2-chloronicotinic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 0 - 20 ℃;
for 1.5h;
methanol;
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 0.5h;
|
|
|
With
sulfuric acid;
|
|
|
With
001*7 cationic resin;
for 5h;
Reagent/catalyst;
Reflux;
|
-
-
2942-59-8
2-chloronicotinic acid
-
-
40134-18-7
methyl 2-chloropyridine-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
thionyl chloride; triethylamine;
In
methanol; toluene;
|
98%
|
|
Multi-step reaction
with
2
steps
1: SOCl2
/ 2.5 h / Heating
2: Et3
N / Ambient temperature
With
thionyl chloride; triethylamine;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / 2 h / Heating
2: 1 h / Heating
With
thionyl chloride;
|
|
|
Multi-step reaction
with
2
steps
1: SOCl2
/ benzene / 3 h / Heating
2: 0.33 h / Heating
With
thionyl chloride;
In
benzene;
|
|
|
With
thionyl chloride;
In
methanol;
|
40134-18-7 Upstream products
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186581-53-3
diazomethane
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2942-59-8
2-chloronicotinic acid
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67-56-1
methanol
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49609-84-9
2-Chloronicotinoyl chloride
40134-18-7 Downstream products
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104813-92-5
2-Piperazin-1-yl-nicotinic acid methyl ester
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157276-72-7
methyl (2-propylamino)nicotinate
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114501-09-6
2-(3-Methoxy-phenylamino)-nicotinic acid methyl ester
-
59361-45-4
methyl 2-((3-(trifluoromethyl)phenyl)amino)nicotinate
