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High Quality Chinese Manufacturer supply 16632-21-6 5-Nitro-6-methyluracil
- Molecular Formula: C5H5N3O4
- Molecular Weight: 171.112
- Appearance/Colour: light yellow crystalline solid
- Melting Point: 290-291 °C
- Refractive Index: 1.583
- PKA: 6.24±0.10(Predicted)
- Flash Point: 215.3 °C
- PSA： 112.06000
- Density: 1.581 g/cm3
- LogP: 0.62760
5-Nitro-6-methyluracil(Cas 16632-21-6) Usage
InChI:InChI=1/C5H5N3O4/c1-2-3(8(11)12)4(9)7-5(10)6-2/h1H3,(H2,6,7,9,10)
16632-21-6 Relevant articles
Structural and Biological Investigations for a Series of N-5 Substituted Pyrrolo[3,2-d]pyrimidines as Potential Anti-Cancer Therapeutics
Cawrse, Brian M.,Robinson, Nia'mani M.,Lee, Nina C.,Wilson, Gerald M.,Seley-Radtke, Katherine L.
, (2019/08/01)
Pyrrolo[3,2-d]pyrimidines have been stud...
Synthesis and biochemical evaluation of lid-open D-amino acid oxidase inhibitors
Szilágyi, Bence,Hargitai, Csilla,Kelemen, ádám A.,Rácz, Anita,Ferenczy, Gy?rgy G.,Volk, Balázs,Keser?, Gy?rgy M.
supporting information, (2019/01/31)
Most of the known inhibitors of D-amino ...
Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution
Cawrse, Brian M.,Lapidus, Rena S.,Cooper, Brandon,Choi, Eun Yong,Seley-Radtke, Katherine L.
, p. 178 - 185 (2017/12/26)
Halogenated pyrrolo[3,2-d]pyrimidine ana...
INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
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Paragraph 0547; 0549, (2018/04/27)
The present disclosure discloses compoun...
16632-21-6 Process route
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626-48-2
6-Methyluracil
-
-
16632-21-6
5-nitro-6-methyluracil
| Conditions | Yield |
|---|---|
|
With
sulfuric acid; nitric acid;
at 0 ℃;
|
83%
|
|
6-Methyluracil;
With
sulfuric acid;
at 0 - 40 ℃;
With
nitric acid;
at 15 - 20 ℃;
for 0.5h;
|
83%
|
|
With
nitric acid; phosphorus pentoxide;
cooling;
|
81%
|
|
With
sulfuric acid; nitric acid;
at 0 - 20 ℃;
for 1h;
|
80%
|
|
With
sulfuric acid; nitric acid;
at 20 ℃;
for 2h;
|
80%
|
|
With
sulfuric acid; nitric acid;
at -2 - 35 ℃;
for 12h;
|
65.2%
|
|
With
sulfuric acid; nitric acid;
|
|
|
With
phosphorus pentaoxide; nitric acid;
|
|
|
With
phosphorus pentaoxide; nitric acid;
In
ice-water;
|
|
|
With
sulfuric acid; nitric acid;
at 20 ℃;
|
|
|
With
sulfuric acid; nitric acid;
at 20 ℃;
|
|
|
With
sulfuric acid; nitric acid;
|
|
|
With
sulfuric acid; nitric acid;
at 20 ℃;
for 0.5h;
|
|
|
With
sulfuric acid; nitric acid;
at 50 ℃;
for 10h;
Inert atmosphere;
|
2.7 g
|
|
With
sulfuric acid; nitric acid;
at 25 ℃;
for 1.5h;
|
-
-
116705-41-0
(E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione
-
-
16632-21-6
5-nitro-6-methyluracil
| Conditions | Yield |
|---|---|
|
With
sodium hydroxide;
at 90 ℃;
|
94%
|
16632-21-6 Upstream products
-
626-48-2
6-Methyluracil
-
116705-41-0
(E)-6-(2-(dimethylamino)vinyl)-5-nitropyrimidine-2,4(1H,3H)-dione
-
626-48-2
2,4-dihydroxy-6-methylpyrimidine
16632-21-6 Downstream products
-
16290-66-7
5-nitro-6-styryl-1H -pyrimidine-2,4-dione
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13162-26-0
2,4-dichloro-6-methyl-5-nitropyrimidine
-
7460-27-7
(2-chloro-6-methyl-5-nitro-pyrimidin-4-yl)-methyl-phenyl-amine
-
55326-07-3
1,3,6-trimethyl-5-nitrouracil
