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Chinese Manufacturer supply 1-(3-chlorophenyl)-2-methylpiperazine 75348-33-3 in stock with high standard
- Molecular Formula: C11H15 Cl N2
- Molecular Weight: 210.706
- Vapor Pressure: 8.68E-05mmHg at 25°C
- Boiling Point: 340.3°C at 760 mmHg
- Flash Point: 159.6°C
- PSA： 15.27000
- Density: 1.11g/cm3
- LogP: 2.53190
1-(3-chlorophenyl)-2-methylpiperazine(Cas 75348-33-3) Usage
|
Chemical class |
Piperazine derivatives |
|
Molecular weight |
208.7 g/mol |
|
Structure |
Piperazine ring with a 3-chlorophenyl group at the 1-position and a methyl group at the 2-position |
|
Pharmacological activities |
Potential effects on the central nervous system |
|
Therapeutic uses |
Studied as a potential drug candidate for antipsychotic and anxiolytic agents |
|
Synthesis |
Used as a precursor in the synthesis of other pharmaceutical compounds |
|
General Description |
1-(3-chlorophenyl)-2-methylpiperazine is a chemical compound that belongs to the class of piperazine derivatives. It is an organic compound with the molecular formula C11H15ClN2 and a molecular weight of 208.7 g/mol. 1-(3-chlorophenyl)-2-methylpiperazine consists of a piperazine ring with a 3-chlorophenyl group attached at the 1-position and a methyl group at the 2-position. 1-(3-chlorophenyl)-2-methylpiperazine has been researched for its potential pharmacological activities, including its effects on the central nervous system. It has been studied as a potential drug candidate for various therapeutic uses, including as an antipsychotic and anxiolytic agent. 1-(3-chlorophenyl)-2-methylpiperazine is also used as a precursor in the synthesis of other pharmaceutical compounds. |
InChI:InChI=1/C11H15ClN2/c1-9-8-13-5-6-14(9)11-4-2-3-10(12)7-11/h2-4,7,9,13H,5-6,8H2,1H3
75348-33-3 Relevant articles
Effect of modifications of the alkylpiperazine moiety of trazodone on 5HT(2A) and α1 receptor binding affinity
Giannangeli, Marilena,Cazzolla, Nicola,Luparini, Maria Rita,Magnani, Maurizio,Mabilia, Massimo,Picconi, Giuseppe,Tomaselli, Mauro,Baiocchi, Leandro
, p. 336 - 345 (2007/10/03)
A series of triazolopyridine derivatives...
75348-33-3 Process route
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98926-55-7
2-(3-chlorobenzamino)propanoic acid ethyl ester
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75348-33-3
1-(3-chlorophenyl)-2-methylpiperazine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
5
steps
1: 89 percent / NH3
, MeONa / methanol / 8 h
2: 73 percent / LiAlH4
/ tetrahydrofuran; diethyl ether / Heating
3: 75 percent / Et3
N / toluene / 6 h / Heating
4: 52 percent / 2 N HCl / 5 h / Heating
5: 1.) LiAlH4
, 2.) aq. NaOH / 1.) Et2
O, reflux, 3 h, 2.) Et2
O, RT, 30 min
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ammonia; sodium methylate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; toluene;
|
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108-42-9
3-chloro-aniline
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75348-33-3
1-(3-chlorophenyl)-2-methylpiperazine
| Conditions | Yield |
|---|---|
|
Multi-step reaction
with
6
steps
1: 87 percent / Et3
N / 12 h / 100 °C
2: 89 percent / NH3
, MeONa / methanol / 8 h
3: 73 percent / LiAlH4
/ tetrahydrofuran; diethyl ether / Heating
4: 75 percent / Et3
N / toluene / 6 h / Heating
5: 52 percent / 2 N HCl / 5 h / Heating
6: 1.) LiAlH4
, 2.) aq. NaOH / 1.) Et2
O, reflux, 3 h, 2.) Et2
O, RT, 30 min
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; ammonia; sodium methylate; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; toluene;
|
75348-33-3 Upstream products
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220910-04-3
1-(3-chlorophenyl)-2-methylpiperazin-6-one
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98926-55-7
2-(3-chlorobenzamino)propanoic acid ethyl ester
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108-42-9
3-chloro-aniline
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220910-08-7
2-(3-chlorobenzamino)propanamine
75348-33-3 Downstream products
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78070-01-6
1-(3-Chloro-phenyl)-2-methyl-4-(3-nitro-pyridin-4-yl)-piperazine
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220909-98-8
1-(3-chlorophenyl)-1-(3-chloro-2-methylpropyl)-3-methylpiperazine
-
78070-02-7
4-[4-(3-Chloro-phenyl)-3-methyl-piperazin-1-yl]-pyridin-3-ylamine
